I'd like to participate, location and time permitting (have to deal with my work schedule).
I don't know that there's any neighborhood that I know well enough to be qualified to lead such a ride.
In addition to talking about the history, points of interest, etc in a neighborhood, it'd also be great to learn about optimal bicycle routing. For example, "never take street X; the traffic lights are timed pessimally", "watch out, people always blow through this stop sign here", "this street is a great short-cut from X to Y", etc.