The bike directions in Google are a good tool, I think.
They suggest the Panhandle trail to WV. I concur. That would get you north of Wheeling. There is a bike path that would take you most of the way to Wheeling.
After that, Google suggests going down the Ohio River Valley, first on the WV side, then crossing over to Ohio. I'd be a little concerned with heavy traffic, particularly industrial trucks, though.
One alternative would be dragging the Google path into Ohio away from the river. It's Appalachian Ohio, so there are hellacious hills, but it could get you away from the traffic.
If I recall correctly, there is a racing group in Marietta. If you found out how to contact them, they might be able to help.